Immune thrombocytopenlc purpura (ITP) and thrombotic thrombocytopenlc purpura (lTP) have each been associated with HIV Infection. Sequential occurrence of these two dlseases with a disease-free interval has been occasionally reported In the literature, whereas simultaneous manifestations of these tw
Concomitant thrombotic thrombocytopenic purpura and ANCA-associated vasculitis in an adolescent
β Scribed by Varun Agrawal; Chirag K. Vaidya; Jiuming Ye; Jonathan Freeman; Christine McKiernan; Peter R. Blier; Chester Andrzejewski; Michael Germain; Gregory L. Braden
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 168 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0931-041X
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## Abstract **Background and purpose:** Thrombotic thrombocytopenic purpura (TTP) is a lifeβthreatening multisystem disorder characterized by thrombocytopenia and fluctuating neurological symptoms due to microinfarcts. In rare cases, large cerebral arteries can be occluded. **Summary of the case:**
Thrombotic thrombocytopenic purpura (TTP) is a disorder of systemic platelet aggregation. Evidence has accumulated that the aggregating agonist in TTP of all types is likely to be von Willebrand factor (vWf), especially unusually large vWf multimers derived from endothelial cells. Recent evidence in
Hemolytic uremic syndrome/thrombotic thrornbocytopenic purpura (HUSITTP) is a rare and often fatal complication of bonc marrow transplantation (BMT). In this study. wc rcport eight such cases (seven allo and onc auto) treated with plasma exchanges (PE), vincristine (six paticnts), and discontinuatio