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Concomitant immunity in hamsters bearing dmba-induced tumor transplants

✍ Scribed by Robert N. Lausch; Fred Rapp

Publisher
John Wiley and Sons
Year
1969
Tongue
French
Weight
359 KB
Volume
4
Category
Article
ISSN
0020-7136

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✦ Synopsis

Hamsters bearing progressively growing DMBA-induced tumor transplants were found to make a specific immune response to the. neoplasm. This response was identified because animals bearing DMBA tumors rejected conrentrations of DMBA-transformed cells that were capable of inducing tumors in normal animals. This concomitant immunity was detectable even when the immunizing and challenge cells were inoculated simultaneously. Animals bearing DMBA-induced tumor cell transplants were not protected against challenge with hamster cells transformed by simian papovavirus S V40, confirming the specificity of the concomitant immunity being studied.

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