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Transplantation immunity to individually unique antigens of chemically induced bladder tumors in mice

✍ Scribed by D. V. Wahl; W. H. Chapman; I. Hellström; K. E. Hellström

Publisher
John Wiley and Sons
Year
1974
Tongue
French
Weight
659 KB
Volume
14
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

We have previously shown that lymphocyte‐mediated immunity to common bladder tumor antigens can be demonstrated in vitro. In this study we used two carcinomas and two sarcomas of the urinary bladder of BALB/c mice to immunize syngeneic animals against tumor‐specific transplantation antigens (TSTA) in order to determine whether common and/or individually unique antigens could be detected by resistance of the mice to challenge with tumor cells. Strong transplantation resistance was induced against each individual tumor line by immunizing with the respective line. No evidence could be obtained for the presence of TSTA common to the two carcinomas or to the two sarcomas (or to all four tumors).

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