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Concise Synthesis of 1H-Pyrazin-2-ones and 2-Aminopyrazines.

โœ Scribed by Isabelle Adam; David Orain; Peter Meier


Book ID
101964890
Publisher
John Wiley and Sons
Year
2005
Weight
19 KB
Volume
36
Category
Article
ISSN
0931-7597

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In this Letter, we report a novel approach to the preparation of 3-anilino-pyrazin-2(1H)-ones and 3-anilino-quinoxalin-2(1H)-ones from the corresponding 3-halo pyrazin-2-amines and 3-haloquinoxalin-2-amines, using a microwave-mediated Smiles rearrangement.