Asymmetric Synthesis of (+)-Tanikolide a
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Robert Doran; Lesley Duggan; Surrendra Singh; Colm D. Duffy; Patrick J. Guiry
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Article
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2011
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John Wiley and Sons
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English
β 770 KB
## Abstract The Ξ΄βlactoneβcontaining natural product (+)βtanikolide, a brine shrimp toxin and antifungal compound, was synthesized in nine steps with an overall yield of 26.4β% by employing Sharpless asymmetric epoxidation and ZrCl~4~βcatalyzed intramolecular acetalization as the key steps. The nov