Michael addition of g-amino alcohol 2 to alkynone 3 affords enamine 4, which is converted into cyclic enamine 6 through its bromide 5. Diastereoselective hydrogenation of 6 followed by protection and epimerization provides piperidine 8. Baeyer-Villiger oxidation of 8 and the subsequent deprotection
✦ LIBER ✦
Concise asymmetric synthesis of (−)-deoxoprosophylline
✍ Scribed by Ru-Cheng Liu; Jin-Hu Wei; Bang-Guo Wei; Guo-Qiang Lin
- Book ID
- 108284420
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 371 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0957-4166
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