𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Concise asymmetric synthesis of (−)-deoxoprosophylline

✍ Scribed by Ru-Cheng Liu; Jin-Hu Wei; Bang-Guo Wei; Guo-Qiang Lin


Book ID
108284420
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
371 KB
Volume
19
Category
Article
ISSN
0957-4166

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Asymmetric synthesis of (−)-deoxoprosoph
✍ Nan Ma; Dawei Ma 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 210 KB

Michael addition of g-amino alcohol 2 to alkynone 3 affords enamine 4, which is converted into cyclic enamine 6 through its bromide 5. Diastereoselective hydrogenation of 6 followed by protection and epimerization provides piperidine 8. Baeyer-Villiger oxidation of 8 and the subsequent deprotection

Asymmetric total synthesis of (−)-deoxop
✍ Angélique Jourdant; Jieping Zhu 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 72 KB

Asymmetric syntheses of (-)-deoxoprosophylline from chiral L-N,N -dibenzyl serine (TBDMS) aldehyde is reported. A highly diastereoselective intramolecular reductive amination of v-oxo amino diol is a key step of the present synthesis.