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Concise and connective synthesis of exo-methylene-γ-butyrolactones

✍ Scribed by Raphaël Dumeunier; Cédric Leclercq; István E Markó

Book ID
104250664
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
94 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

A novel sequence, combining an ene-reaction of the substituted allylsilane 2 with a variety of aldehydes, followed by an oxidative double desilylation, provides an efficient access to a wide range of exo-methylene-g-butyrolactones.

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Efficient and connective synthesis of su
Efficient and connective synthesis of substituted butyrolactones and exo-methylene butyrolactones
✍ Bernard Leroy; Raphaël Dumeunier; István E Markó 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 59 KB

A variety of a-(trimethylsilylmethyl)-substituted butyrolactones are readily accessed by a novel tandem ene-reaction/oxidative desilylation of a range of aldehydes. Subsequent functionalisation led to an efficient methodology for the preparation of exo-methylene butyrolactones.