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Concerning the Solvent Effect in the Aldol Condensation

✍ Scribed by Yanhe Huang


Publisher
Springer Vienna
Year
2000
Tongue
English
Weight
53 KB
Volume
131
Category
Article
ISSN
0026-9247

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The stereochemical results in an aldol reaction between the enolate 2 and various a-methyl aldehydes indicates a stabilizing through space interaction between C4-C s unsaturation and the formyl group. This interaction leads to a reaction conformation which favors a C7-C ~ (epothilone numbering) ant