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Concentration-Dependent Dissociation/Association of Human Prostatic Acid Phosphatase

✍ Scribed by Ewa Luchter-Wasylewska; Marcin Wasylewski; Klaus-Heinrich Röhm

Book ID
111547094
Publisher
Springer
Year
2003
Tongue
English
Weight
71 KB
Volume
22
Category
Article
ISSN
1573-4943

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Further investigation of the structural requirements of a series of benzylphosphonic acid inhibitors of human prostatic acid phosphatase has led to the highly potent series of a-aminobenzylphosphonic acids. The a-benzylaminobenzylphosphonic acid, with an IC~o = 4 nM, exhibited a 3500-fold improvemen