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Benzylphosphonic acid inhibitors of human prostatic acid phosphatase

✍ Scribed by Charles F. Schwender; Scott A. Beers; Elizabeth A. Malloy; Jacqueline J. Cinicola; David J. Wustrow; Keith D. Demarest; Jerold Jordan

Book ID
108038971
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
171 KB
Volume
6
Category
Article
ISSN
0960-894X

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✍ Scott A. Beers; Charles F. Schwender; Deborah A. Loughney; Elizabeth Malloy; Kei πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 585 KB

Further investigation of the structural requirements of a series of benzylphosphonic acid inhibitors of human prostatic acid phosphatase has led to the highly potent series of a-aminobenzylphosphonic acids. The a-benzylaminobenzylphosphonic acid, with an IC~o = 4 nM, exhibited a 3500-fold improvemen