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Concentration dependency of theophylline plasma protein binding

โœ Scribed by H. Tajerzadeh; S. Dadashzadeh; G. Rostami


Book ID
118111039
Publisher
Pharmaceutical Press
Year
1998
Tongue
English
Weight
103 KB
Volume
50
Category
Article
ISSN
2042-7158

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The binding of diazepam (DZ) and its major metabolite desmethyldiazepam (DMDZ) to plasma protein was evaluated in a series of controlled in vitro studies using equilibrium dialysis. Free fraction (FF) of both drugs alone changed significantly with total plasma drug concentration, but the increased F