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Computer-Guided Design, Synthesis, and Protein Kinase C Affinity of a New Salicylate-Based Class of Bryostatin Analogs

โœ Scribed by Wender, Paul A.; Nakagawa, Yu; Near, Katherine E.; Staveness, Daryl

Book ID
126979389
Publisher
American Chemical Society
Year
2014
Tongue
English
Weight
610 KB
Volume
16
Category
Article
ISSN
1523-7060

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Synthesis and biological evaluation of a
Synthesis and biological evaluation of a new class of bryostatin analogues: the role of the C20 substituent in protein kinase C binding
โœ Paul A Wender; Kevin W Hinkle ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 178 KB

The synthesis and biological assay of a new series of designed bryostatin analogues modiยฎed at the C20 position are described. These compounds are found to bind to protein kinase C with anities of up to 1.5 nM, demonstrating that variations at C20 can indeed be used to tune anity and potentially fun