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ChemInform Abstract: Synthesis and Biological Evaluation of a New Class of Bryostatin Analogues: The Role of the C20 Substituent in Protein Kinase C Binding.

โœ Scribed by Paul A. Wender; Kevin W. Hinkle


Book ID
111699152
Publisher
John Wiley and Sons
Year
2000
Weight
28 KB
Volume
31
Category
Article
ISSN
0931-7597

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Synthesis and biological evaluation of a
โœ Paul A Wender; Kevin W Hinkle ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 178 KB

The synthesis and biological assay of a new series of designed bryostatin analogues modiยฎed at the C20 position are described. These compounds are found to bind to protein kinase C with anities of up to 1.5 nM, demonstrating that variations at C20 can indeed be used to tune anity and potentially fun