Synthesis and biological evaluation of a
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Paul A Wender; Kevin W Hinkle
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Article
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2000
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Elsevier Science
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French
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The synthesis and biological assay of a new series of designed bryostatin analogues modiยฎed at the C20 position are described. These compounds are found to bind to protein kinase C with anities of up to 1.5 nM, demonstrating that variations at C20 can indeed be used to tune anity and potentially fun