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Computer-generated graphic models of the N2-substituted deoxyguanosine adducts of 2-acetylaminofluorene and benzo[a]pyrene and the O6-substituted deoxyguanosine adduct of 1-naphthylamine in the DNA double helix

โœ Scribed by Frederick A. Beland


Book ID
113135966
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
527 KB
Volume
22
Category
Article
ISSN
0009-2797

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Novel trifluoroethanol mediated synthesi
โœ Andagar R Ramesha; Heiko Kroth; Donald M Jerina ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 74 KB

The exocyclic amino groups of deoxyadenosine and deoxyguanosine readily add to C-10 of the benzo[a]pyrene 7,8-diol 9,10-epoxides at room temperature overnight in trifluoroethanol. Whereas the dG adducts are obtained as a mixture of cis-and trans-opened diastereomers, the dA adducts arise exclusively