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Computational study of the hydrolysis of degradable polysaccharide biomaterials: Substituent effects on the hydrolytic mechanism

✍ Scribed by Lawrence M. Pratt; C. C. Chu

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
578 KB
Volume
15
Category
Article
ISSN
0192-8651

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✦ Synopsis

Hyaluronic acid and its derivatives are absorbable polysaccharides which are used extensively in cosmetics and as biomaterials. Two possible mechanisms of degradation, involving an oxocarbenium ion and the corresponding radical cation, are examined by modeling of the saccharide ring and the effects of various ring substituents on the two possible mechanisms.

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