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Computational modeling and design of renin inhibitors

✍ Scribed by Subramanian, Govindan


Book ID
118204511
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
491 KB
Volume
23
Category
Article
ISSN
0960-894X

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Two types of P1-P3-linked macrocyclic renin inhibitors containing the hydroxyethylene isostere (HE) scaffold just outside the macrocyclic ring have been synthesized. An aromatic or aliphatic substituent (P3sp) was introduced in the macrocyclic ring aiming at the S3 subpocket (S3sp) in order to optim

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