Computational Methods for Processing and Analysis of Biological Pathways

✍ Scribed by Anastasios Bezerianos, Andrei Dragomir, Panos Balomenos (auth.)

• Publisher: Springer International Publishing
• Year: 2017
• Tongue: English
• Leaves: 96
• Series: SpringerBriefs in Computer Science
• Edition: 1
• Category: Library

✦ Synopsis

This work offers a guided walkthrough of one of the most promising research areas in modern life sciences, enabling a deeper understanding of involved concepts and methodologies via an interdisciplinary view, focusing on both well-established approaches and cutting-edge research. Highlighting what pathway analysis can offer to both the experimentalist and the modeler, the text opens with an introduction to a general methodology that outlines common workflows shared by several methods. This is followed by a review of pathway and sub-pathway based approaches for systems pharmacology. The work then presents an overview of pathway analysis methods developed to model the temporal aspects of drug- or disease-induced perturbations and extract relevant dynamic themes. The text concludes by discussing several state-of-the-art methods in pathway analysis, which address the important problem of identifying differentially expressed pathways and sub-pathways.

✦ Table of Contents

Front Matter....Pages i-viii
Introduction....Pages 1-10
Networks and Pathways in Systems Pharmacology....Pages 11-46
Time-Varying Methods for Pathway and Sub-pathway Analysis....Pages 47-68
Identification of Differentially Expressed Pathways and Sub-pathways....Pages 69-87

✦ Subjects

Computational Biology/Bioinformatics;Systems Biology