𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Computational investigations of the stereoselectivities of proline-related catalysts for aldol reactions

✍ Scribed by Christophe Allemann; Joann M. Um; K.N. Houk

Book ID
103835218
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
949 KB
Volume
324
Category
Article
ISSN
1381-1169

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Computational Evidence for the Enamine M
Computational Evidence for the Enamine Mechanism of Intramolecular Aldol Reactions Catalyzed by Proline
✍ Fernando R. Clemente; K. N. Houk πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 336 KB

Theoretical evidence now suggests that the mechanism of the longdebated Hajos-Parrish-Eder-Sauer-Wiechert reaction, the prototype for asymmetric organocatalytic reactions, involves a proline enamine intermediate (center) which undergoes a concerted aldol cyclization with proton transfer. For more de

Enhanced Activity and Stereoselectivity
Enhanced Activity and Stereoselectivity of Polystyrene-Supported Proline-Based Organic Catalysts for Direct Asymmetric Aldol Reaction in Water
✍ Michelangelo Gruttadauria; Anna Maria Pia Salvo; Francesco Giacalone; Paola Agri πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 580 KB

## Abstract Several polystyrene‐supported proline dipeptides and a prolinamide derivative were prepared by thiol–ene coupling. These materials were used as catalysts for the direct asymmetric aldol reaction in water, and results compared with unsupported catalysts in water. Such an approach gave mo