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Computational design strategies for combinatorial libraries

โœ Scribed by Sally Rose; Adrian Stevens

Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
281 KB
Volume
7
Category
Article
ISSN
1367-5931

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โœฆ Synopsis

Medicinal chemistry principles are being increasingly applied to the design of smaller, high purity, information-rich libraries. Recent computational advances in statistical methodology, the design of libraries to reduce ADMET problems, targeting protein families and revisiting natural products as sources of inspiration for scaffolds and reagents are all areas of progressive research.

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