Simulation modelling of human intestinal
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Simon Thomas; Frances Brightman; Helen Gill; Sally Lee; Boris Pufong
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Article
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2008
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John Wiley and Sons
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English
โ 218 KB
Measurement of permeation across a monolayer of the human adenocarcinoma cell line, Caco-2, is a popular surrogate for a compound's permeation across the human intestinal epithelium. Taken alone, however, Caco-2 permeability has certain limitations in the prediction of the extent of absorption of an