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Computational approaches for modeling human intestinal absorption and permeability

โœ Scribed by Govindan Subramanian; Douglas B. Kitchen


Publisher
Springer-Verlag
Year
2006
Tongue
English
Weight
245 KB
Volume
12
Category
Article
ISSN
1610-2940

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Measurement of permeation across a monolayer of the human adenocarcinoma cell line, Caco-2, is a popular surrogate for a compound's permeation across the human intestinal epithelium. Taken alone, however, Caco-2 permeability has certain limitations in the prediction of the extent of absorption of an