Computation of writhe in modeling of supercoiled DNA
✍ Scribed by Konstantin Klenin; Jörg Langowski
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2000
- Tongue
- English
- Weight
- 192 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0006-3525
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The equilibrium shapes of supercoiled DNA are investigated by employing an elastic model. First, a set of Euler equations is derived to determine the equilibrium shapes under ring-closure conditions. Two exact solutions that describe circular and figure-8 shapes are obtained. Using these and their t
## Synopsis DNA supercoiling is both an interesting problem from the theoretical point of view and an important phenomenon affecting DNA functions in viuo. Experimentally, however, hardly more than the overall hydrodynamic shape, superhelical density, and enzymic or chemical reactivity of the para
## Abstract Covalently closed circular DNA can exist in different configurations known as __circular__, __toroidal__, and __interwound__. Changes among these forms can be made in several ways, including the insertion of dye molecules between adjacent base pairs, which tends to untwist the double‐he