## Abstract Polymorphisms in DNA repair genes may be associated with differences in the capacity to repair DNA damage and thereby influence an individual's susceptibility to smokingโrelated cancer. To test this hypothesis, we investigated the potential association of 7 __XPC__ polymorphisms (โ449Gโ
Comprehensive assessment ofP21polymorphisms and lung cancer risk
โ Scribed by Yi Young Choi; Hyo-Kyung Kang; Jin Eun Choi; Jin Sung Jang; Eun Jin Kim; Sung Ick Cha; Won Kee Lee; Sin Kam; Chang Ho Kim; Sung Beom Han; Tae Hoon Jung; Jae Yong Park
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 280 KB
- Volume
- 53
- Category
- Article
- ISSN
- 1435-232X
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## Abstract Microsomal epoxide hydrolase (mEPHX) is a critical metabolic enzyme involved in the activation and subsequent detoxification of specific tobacco carcinogens. __mEPHX__ harbors polymorphisms in exon 3 and exon 4 that modulate enzymatic activity. The exon 3 polymorphism decreases mEPHX me