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Complex Segregation Analysis on Sib-Pairs Data

✍ Scribed by J. J. Tai; Prof. Alan J. Gross

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
399 KB
Volume
30
Category
Article
ISSN
0323-3847

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✦ Synopsis

Using sib-pairs and parent-pairs data, a quantitative trait can be tested for the existence of a major locus under the mixed model of MORTON and B ~C L E A N (1974). The basic idea is t j obtain the two conditional likelihoods for sib-pair differences and parent-pair differences provided that it is known which sib-pairs or parent-pairs have the same effect at the major locus. Two conditions are introduced to obtain two recursive computer algorithms that distinguish the sib-pairs or parent-pairs having the same effect at the major locus. This method has the advantage of reducing complicated computations involving maximum likelihood estimates from nuclear families. A simulation experiment is performed to illustrate the method and its results are discussed.

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