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Complex Segregation Analysis on Multi-Modal Distributions

✍ Scribed by Dr. J. J. Tai; Prof. Dr. A. J. Gross

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
370 KB
Volume
31
Category
Article
ISSN
0323-3847

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✦ Synopsis

By using eib-pairs and parent-pairs data, proposed a method to test the existence of a 2-allele major locus for a quantitative trait. This method is extended to include three alleles at a major locus in this paper. One may perform this extension in a feasible and practical manner. To show the advantage of this extension, 8 simulated data set of nuclear families from a 3-allele ordered dominant (i.e., A > B, A =-W and B > W in our notation) major locus model for a quantitative trait is analyzed by a 2-allele codominant major locus mixed model and a 3-allele ordered dominant major locus mixed model. The result shows that our method can distinguish between ambiguous trimodal distributions.

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