Statistical genetic mapping methods are powerful tools for "nding genes that contribute to complex human traits. Mapping methods combine knowledge of the biological mechanisms of inheritance and the randomness inherent in those mechanisms to locate, with increasing precision, trait genes on the huma
Complex phenotypes and complex genetics: An introduction to genetic studies of complex traits
β Scribed by John W. Belmont; Suzanne M. Leal
- Book ID
- 107533865
- Publisher
- Current Science Inc.
- Year
- 2005
- Tongue
- English
- Weight
- 212 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1523-3804
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This chapter surveys current major approaches to mapping genes for multifactorial human diseases using either family-based or population-based samples. Complex, multifactorial diseases are generally hypothesized to be attributable to the effects of multiple genes with incomplete penetrance. Gene-gen