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Completing the Arc: Targeted Inhibition of RET in Medullary Thyroid Cancer

✍ Scribed by Houvras, Y.


Book ID
118161984
Publisher
American Society of Clinical Oncology
Year
2012
Tongue
English
Weight
110 KB
Volume
30
Category
Article
ISSN
0732-183X

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Medullary thyroid carcinoma (MTC) occurs sporadically or as part of the inherited cancer syndrome multiple endocrine neoplasia (MEN) type 2. In MEN 2A, germline missense mutations are found in one of five cysteine codons within exons 10 and I I in the extracellular domain of the RET protooncogene. I