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Complete spectral assignments of cevadine and veratridine by 2D NMR techniques

✍ Scribed by V. V. Krishnamurthy; John E. Casida

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
789 KB
Volume
26
Category
Article
ISSN
0749-1581

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✦ Synopsis

The long-range CH correlation NMR experiment (with decoupling of modulation of intensities due to one-bond couplings during refocusing) and the double quantum coherence correlation spectroscopy (DQCOSY) experiment were used, together with the standard one-bond CH correlation and COSY spectra, for complete ''C and 'H spectral peak assignments of veratrine (a 2: 1 mixture of cevadine and veratridine). The long-range CH correlation experiment determined the long-range CH connectivity network, thus indirectly providing carbon-carbon connectivity. The DQCOSY experiment proved to be a complementary technique to the standard COSY experiment in unraveling and/or confirming proton-proton connectivities in this highly crowded proton spectrum.

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