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Complete Regioselective Addition of Grignard Reagents to Pyrazine N-Oxides, Toward an Efficient Enantioselective Synthesis of Substituted Piperazines

✍ Scribed by Andersson, Hans; Banchelin, Thomas Sainte-Luce; Das, Sajal; Gustafsson, Magnus; Olsson, Roger; Almqvist, Fredrik


Book ID
111677189
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
224 KB
Volume
12
Category
Article
ISSN
1523-7060

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Regioselective Addition of Organometalli
✍ Xiuzhao Yu; Junliang Zhang πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 166 KB πŸ‘ 2 views

## Abstract Highly substituted 1,2‐allenyl ketones can be easily and efficiently prepared from organometallic reagents and readily available 2‐(1‐alkynyl)‐2‐alken‐1‐ones. The synthetic application of 1,2‐allenyl ketone products was also showcased by palladium‐catalyzed further transformation.