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Complement-mediated unspecific binding of immunoglobulins to some endocrine cells

✍ Scribed by R. Buffa; O. Crivelli; R. Fiocca; P. Fontana; E. Solcia

Book ID: 104789318
Publisher: Springer
Year: 1979
Tongue: English
Weight: 878 KB
Volume: 63
Category: Article
ISSN: 1432-119X
DOI: 10.1007/bf00508008

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✦ Synopsis

Unspecific binding of immunoglobulins to gastrin G cells, glucagon A cells and somatostatin D cells of the gastric mucosa or pancreas, as well as to the calcitonin-somatostatin cells of rabbit thyroid has been found to occur through a non antigen-antibody mechanism mediated at least in part by the C1q fraction of complement. The phenomenon represents a major drawback in hormone immunohistochemistry, which can be prevented by incubating the specific anti-hormone sera with anti-C1q antibodies or with complement-fixing immunocomplexes.

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