Decreased Complement Mediated Binding of Antibody/3H-dsDNA Immune Complexes to the Red Blood Cells of Patients with Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Hematologic Malignancies

✍ Scribed by Ronald P. Taylor; Carol Horgan; Ralph Buschbacher; Carolyn M. Brunner; Charles E. Hess; William M. O'Brien; Harold J. Wanebo

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 817 KB
• Volume: 26
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780260606

✦ Synopsis

The complement mediated binding of prepared antib~dy/~H-dsDNA immune complexes to the red blood cells obtained from a number of patient populations has been investigated. Patients with solid tumors have binding activity similar to that seen in a normal group of individuals. However, a significant fraction of patients with systemic lupus erythematosus, rheumatoid arthritis, and hematologic malignancies have lowered binding activity compared with normal subjects. Quantitative studies indicate the lowered activity probably arises due to a decrease in complement receptors on the respective red blood cells. The potential importance and implications of these findings are briefly discussed.

Almost 30 years ago Nelson (1) first reported that complement-fixing immune complexes bind to human erythrocytes via a receptor that has been characterized as specific for C3b and C4b (1-3). Recent studies of this immune adherence receptor (CR,) indicate that it is found at varying densities on the surfaces of a number of circulating cells (2,3). The vast