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Complement factor H and hemolytic uremic syndrome

✍ Scribed by Peter F. Zipfel; Christine Skerka; Jessica Caprioli; Tamara Manuelian; Hartmut H. Neumann; Marina Noris; Giuseppe Remuzzi


Book ID
117797796
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
111 KB
Volume
1
Category
Article
ISSN
1567-5769

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De novo gene conversion in the RCA gene
✍ Stefan Heinen; Pilar Sanchez-Corral; Michael S Jackson; Lisa Strain; Judith A. G πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 315 KB

Many of the complement regulatory genes within the RCA cluster (1q32) have arisen through genomic duplication and the resulting high degree of sequence identity is likely to predispose to gene conversion events. The highest degree of identity is between the genes for factor H (CFH) and five factor H