Complement-dependent hematopoietic inhibitors in the sera of patients with aplastic anemia and paroxysmal nocturnal hemoglobinuria
β Scribed by Masuhiro Takahashi
- Book ID
- 112212132
- Publisher
- AlphaMed Press
- Year
- 1987
- Tongue
- English
- Weight
- 998 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1066-5099
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## Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is a debilitating and lifeβthreatening disease in which lysis of PNH red blood cells frequently manifests with chronic hemolysis, anemia, and thrombosis. Renal damage in PNH is associated with chronic hemosiderosis and/or microvascular thrombosi
The relationships between paroxysmal nocturnal hemogloblnuria (PNH), aplastlc anemia (AA), and myelodysplastlc syndrome (MDS) are not clear. Here we describe a patient, J20, who developed a reciprocal translocation of chromosome 12 and PNH during follow-up of AA. All metaphases In CD59-deflcient bon