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Complement dependent cytotoxicity in chronic lymphocytic leukemia: ofatumumab enhances alemtuzumab complement dependent cytotoxicity and reveals cells resistant to activated complement

✍ Scribed by Baig, Nisar A.; Taylor, Ronald P.; Lindorfer, Margaret A.; Church, Amy K.; Laplant, Betsy R.; Pavey, Emily S.; Nowakowski, Grzegorz S.; Zent, Clive S.


Book ID
126646000
Publisher
Informa plc
Year
2012
Tongue
English
Weight
436 KB
Volume
53
Category
Article
ISSN
1042-8194

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Direct and complement dependent cytotoxi
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The mechanism of cytotoxicity of alemtuzumab and rituximab in chronic lymphocytic leukemia (CLL) is not well understood. We obtained fresh CLL cells from early-intermediate stage high-risk patients just prior to treatment with alemtuzumab and rituximab to study mechanisms of action and resistance. A