Complement activation in rheumatoid arthritis evaluated by C3dg and the terminal complement complex
✍ Scribed by Tom E. Mollnes; Tor Lea; Ove J. Mellbye; Jan Pahle; Øyvind Grand; Morten Harboe
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 664 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0004-3591
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## Abstract Analyses of CH50, complement components, properdin factors, and kininogen in synovial fluid of patients with juvenile rheumatoid arthritis revealed evidence of activation of the classic complement pathway in all clinical subgroups. Juveniles with the adult pattern of disease had the gre
## Abstract A simple, sensitive solid‐phase radioimmunoassay to quantitate the activation of the classical pathway of complement by rheumatoid factor (RF) is described. RF (purified, in serum or synovial fluid) was bound to reduced and alkylated IgG adsorbed to polyvinyl chloride microtiter plates
Synovial fluid (SF) and synovial tissue from 10 patients with juvenile rheumatoid arthritis were examined. The SFs were heterogeneous with respect to the degree of complement activation. Quantification of C3dg and the terminal complement complex revealed a positive correlation between activation of