Comparisons of Two Methods for Haplotype Reconstruction and Haplotype Frequency Estimation from Population Data
β Scribed by Shuanglin Zhang; Andrew J. Pakstis; Kenneth K. Kidd; Hongyu Zhao
- Book ID
- 117853705
- Publisher
- American Society of Human Genetics
- Year
- 2001
- Tongue
- English
- Weight
- 250 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0002-9297
- DOI
- 10.1086/323622
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## Abstract Haplotype inference for tightly linked markers from general pedigrees remains a challenging problem. Only a few methods are available to efficiently and accurately estimate haplotype frequencies and reconstruct haplotypes for a large number of tightly linked markers from general pedigre
The program which is written in FORTRAN estimates haplotype frequencies in two-locus and three-locus genetic systems from population diploid data. It is based on the gene counting method which leads to maximum likelihood estimates, and can be used whenever the possible antigens (one or more) on each