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Comparison of the Pharmacokinetics and Pharmacodynamics of the Aldose Reductase Inhibitors, AL03152 (RS), AL03802 (R), and AL03803 (S)

โœ Scribed by Young Han Park; Philip R. Mayer; Ronnie Barker; Mark DuPriest; Brenda W. Griffin; Gary W. Williams; Billie M. York; John T. Slattery

Book ID
110380172
Publisher
Springer US
Year
1993
Tongue
English
Weight
677 KB
Volume
10
Category
Article
ISSN
0724-8741

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The catalytic and inhibitory profiles of xylose reductase isolated from the yeast Pachysolen tanno- philus (PTXR) are compared to those of aldose reductase (AR) obtained form rat lens. While both PTXR and rat lens AR are NADPH-specific enzymes and have an affinity for a variety of substrates such as