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Comparison of the mutations at Hprt exon 3 of T-lymphocytes from B6C3F1 mice and F344 rats exposed by inhalation to 1,3-butadiene or the racemic mixture of 1,2:3,4-diepoxybutane

✍ Scribed by Quanxin Meng; Navjot Singh; Robert H Heflich; Michael J Bauer; Vernon E Walker


Book ID
117767905
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
241 KB
Volume
464
Category
Article
ISSN
1383-5718

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Increased frequency of mutations at A:T
✍ Leslie Recio; Kathy G. Meyer πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 676 KB

W e have examined the spectra of mutations in a collection of 7 4 lac1 mutants isolated from the bone marrow of B6C3F1 lac1 transgenic mice exposed to 1,250 ppm 1,3-butadiene (BD). Of the 49 inde pendent mutations analyzed in the present study, 30 of 49 (61 %) were point mutations at G:C base pairs,