Background and Objectives: We investigated whether expression levels of c-erbB-2 and p53 proteins in breast cancer tissues differ in primary and metastatic lesions. Methods: Immunohistochemical staining or sandwich enzyme immunoassay was used to determine expression levels of c-erbB-2 and p53 protei
Comparison of the immunohistochemical expression of EGFR, c-erbB2 and p53 protein between primary and recurrent breast cancer
โ Scribed by Shinichi Tsutsui; Shinji Ohno; Shigeru Murakami; Akemi Kataoka; Junko Kinoshita; Yoichi Hachitanda
- Publisher
- Springer Japan
- Year
- 2002
- Tongue
- English
- Weight
- 638 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1340-6868
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๐ SIMILAR VOLUMES
The immunohistochemical expression of p53 and c-erbB-2 gene proteins was examined in a series of 130 breast adenocarcinomas. This study intended to investigate whether the frequency of the altered expression of the tumour suppressor gene p53 and the overexpression of the oncogene c-erbB-2 in breast
## Background: In view of the cumulative results to date, p53, nm23, erbb-2, and cathepsin d are the most promising investigational prognostic factors in breast cancer. ## Objectives: The clinical utility of these molecular markers to predict recurrence was evaluated. ## Methods: Archival patho