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Comparison of the expression of β-catenin in hepatocellular carcinoma in areas with high and low levels of exposure to aflatoxin B1

✍ Scribed by Ke Chen Ban; Harjit Singh; R. Krishnan; Heng Fong Seow

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
296 KB
Volume
86
Category
Article
ISSN
0022-4790

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✦ Synopsis

Abstract

Background and Objectives

Previous studies showed that the frequency of β‐catenin mutation was different in mice when induced by different chemicals. The aim of this study is to compare the expression of β‐catenin and p53 in hepatocellular carcinoma (HCC) from areas with exposure to high and low levels of aflatoxin B1 (AFB1).

Methods

Thirty‐five and twenty HCC samples from Guangxi and Malaysia, respectively, were studied. The expression of β‐catenin and p53 was determined by immunohistochemistry.

Results

The overexpression of β‐catenin was detected in 65.7% of HCC tissues and 37.1% in adjacent liver tissues samples from Guangxi, China. Similarly, overexpression of β‐catenin was also detected in 60.0% of HCC tissues and in 35.0% of adjacent liver tissues samples from Malaysia. The overexpression of p53 was detected in 42.9% of HCC specimens from Guangxi and in 25.0% of HCC specimens from Malaysia. There was a relationship between the expression of β‐catenin and hepatitis B virus (HBV) infection in the adjacent liver tissues in Guangxi, and between the expression of β‐catenin and p53 in HCC tissues in Malaysia.

Conclusions

The differences in the exposure to AFB1 did not affect the overexpression of β‐catenin in the development of HBV‐associated HCC. J. Surg. Oncol. 2004;86:157–163. © 2004 Wiley‐Liss, Inc.

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