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Comparison of the enantiomers of (±)-doxanthrine, a high efficacy full dopamine D1 receptor agonist, and a reversal of enantioselectivity at D1 versus alpha2C adrenergic receptors

✍ Scribed by Julie A. Przybyla; Juan P. Cueva; Benjamin R. Chemel; K. Joseph Hsu; David J. Riese II; John D. McCorvy; Julia A. Chester; David E. Nichols; Val J. Watts


Book ID
118436965
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
649 KB
Volume
19
Category
Article
ISSN
0924-977X

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Herein, we evaluate the interaction of the ␣ 2 -AR antagonist, yohimbine, as compared to fluparoxan, at multiple monoaminergic receptors and examine their roles in the modulation of adrenergic, dopaminergic and serotonergic transmission in freelymoving rats. Yohimbine displays marked affinity at hum