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Comparison of the effects of sibutramine versus sibutramine plus metformin in obese women

✍ Scribed by Ramazan Sari; Esin Eray; Sabahat Ozdem; Halide Akbas; Erkan Coban


Publisher
Springer
Year
2009
Tongue
English
Weight
231 KB
Volume
10
Category
Article
ISSN
0372-8722

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ChemInform Abstract: Synthesis of Sibutr
✍ J. E. JEFFERY; F. KERRIGAN; T. K. MILLER; G. J. SMITH; G. B. TOMETZKI πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 32 KB

Synthesis of Sibutramine, a Novel Cyclobutylalkylamine Useful in the Treatment of Obesity, and Its Major Human Metabolites. -A short and convenient pathway to sibutramine (VII) and some of its demethylated (cf. (V)) and hydroxylated (cf. (XI)) human metabolites is presented. One of the key steps is