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Comparison of the Effects of ORG 30029, Dobutamine and High Perfusate Calcium on Function and Metabolism in Rat Heart

✍ Scribed by Donald J. Grandis; Guy A. MacGowan; Alan P. Koretsky

Book ID: 115632752
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 150 KB
Volume: 30
Category: Article
ISSN: 0022-2828
DOI: 10.1006/jmcc.1998.0817

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## Background: In perfused hearts, high calcium-induced inotropy results in less developed pressure relative to myocardial oxygen consumption compared to the β-adrenergic agonist dobutamine. Calcium handling is an important determinant of myocardial oxygen consumption. Therefore, we hypothesized t