Comparison of the effects of inhibitors of aldose reductase and sorbitol dehydrogenase on neurovascular function, nerve conduction and tissue polyol pathway metabolites in streptozotocin-diabetic rats
โ Scribed by N. E. Cameron; M. A. Cotter; M. Basso; T. C. Hohman
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 176 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0012-186X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
A possible relationship between increased sorbitol concentration and decreased myo-inositol concentration in peripheral nerves of diabetic rats has been examined. To this end, sorbinil, an aldose reductase inhibitor, was used either to prevent or reverse elevation of nerve sorbitol concentration in
This study describes reduced motor nerve conduction velocity and increased resistance to hypoxia-induced conduction failure in sciatic nerves of rats after four weeks of streptozotocin-induced diabetes (both effects were significant at p < 0.05). These changes occurred in the absence of any deficit