Comparison of the effects of fenoldopam, SK&F R-87516 and dopamine on renal arterioles in vitro
โ Scribed by Richard M. Edwards
- Book ID
- 115880400
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 285 KB
- Volume
- 126
- Category
- Article
- ISSN
- 0014-2999
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The present study was carried out to perform a dose-response analysis of the effect of fenoldopam, a DA-1 receptor agonist, on renal sodium excretion. Infusions of fenoldopam for 30 min at doses of 0.125, 0.25, 0.5, and 1.0 pg/kg/min in four separate groups of pentobarbital-anesthetized dogs caused
SK&F 85174 is a mixed DA-l/DA-2 receptor agonist which is shown to inhibit sympathetic neurotransmission and cause hypotension in anesthetized animals. In this study, we have determined the regional and systemic hemodynamic effects of an intravenous infusion of SK&F 85174 (5 pg/kg/min for 5 min) in