Renal, cardiac, and systemic hemodynamic effects of the dopamine receptor agonist SK&F 85174 in anesthetized dogs
✍ Scribed by Abdallah Dlewati; Dr. Mustafa F. Lokhandwala; Jacques E. Chelly; Marie-Francoise Doursout
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 400 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0272-4391
No coin nor oath required. For personal study only.
✦ Synopsis
SK&F 85174 is a mixed DA-l/DA-2 receptor agonist which is shown to inhibit sympathetic neurotransmission and cause hypotension in anesthetized animals. In this study, we have determined the regional and systemic hemodynamic effects of an intravenous infusion of SK&F 85174 (5 pg/kg/min for 5 min) in pentobarbital-anesthetized dogs and attempted to identify the dopamine receptor subtype(s) involved in the cardiac as well as vascular effects of this compound. SK&F 851 74 produced significant decreases in mean blood pressure (MBP), left ventricular pressure (LVP), left ventricular dpidt, total peripheral resistance (TPR) and renal vascular resistance (RVR), and a significant increase in renal blood flow (RBF). There were no significant changes in heart rate, cardiac output, coronary blood flow, or coronary vascular resistance. Prior treatment with SCH 23390 (DA-1 receptor antagonist) significantly attenuated the effects of SK&F 851 74 on MBP, LVP, TPR, RBF, and RVR. In a second group of dogs S-sulpiride (DA-2 receptor antagonist) significantly antagonized the effects of SK&F 85174 on MBP, LVP, and dpidt, but did not influence its effects on RBF, TPR, and RVR. These results show that a) a decrease in total peripheral resistance and not the cardiac output accounts for the hypotensive action of SK&F 85174, b) the renal hemodynamic effects of SK&F 85174 are mediated primarily via the activation of DA-I