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COMPARISON OF THE EFFECT OF DIFFERENT SHORT CHAIN FATTY ACIDS ON THE GROWTH AND DIFFERENTIATION OF HUMAN COLONIC CARCINOMA CELL LINESIN VITRO

✍ Scribed by SAMILA SIAVOSHIAN; HERVÉ M BLOTTIÈRE; ERIC LE FOLL; BERTRAND KAEFFER; CHRISTINE CHERBUT; JEAN-PAUL GALMICHE

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
167 KB
Volume
21
Category
Article
ISSN
1065-6995

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✦ Synopsis

Abstract

The aim of this study was to compare the effects of acetate, propionate, butyrate, iso‐butyrate, valerate, iso‐valerate and caproate on cell growth and on the activities of alkaline phosphatase (AP) and dipeptidyl aminopeptidase IV (DPP IV) by three human colonic adenocarcinoma cell lines. In addition to butyrate, propionate and valerate inhibited cell proliferation of the three cell lines. The other SCFAs did not influence cell proliferation. AP and DPP IV activities were strongly stimulated by butyrate on two of the three cell lines. On HT‐29, AP was strongly stimulated, however DPPIV expression remained undetectable. Propionate and valerate exhibited a weaker stimulation, the other SCFAs being ineffective. The effect of SCFAs on cell proliferation and differentiation clearly depends on the number of carbons and on the configuration of the basic structure of the molecule.

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