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Comparison of the conformations of cyclolinopeptide a in the solid state and in solution

✍ Scribed by T. Tancredi; G. Zanotti; F. Rossi; E. Benedetti; C. Pedone; P. A. Temussi

Publisher: Wiley (John Wiley & Sons)
Year: 1989
Tongue: English
Weight: 609 KB
Volume: 28
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.360280145

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✦ Synopsis

Synopsis

Cyclolinopeptide A, a cyclic nonapeptide isolated from linseed, has lately attracted large interest for i t s cytoprotective activity. The recent elucidation of its solid state structure has prompted us to undertake a detailed conformational analysis in solution. Room-temperature 'H-nmr spectra in several solvents (DMSO-d,, DMSO-d,/qO/H,O, CD,OH, (CD,),CDOH, CDCl,) all show very broad lines, indicating the presence of chemical exchange among several conformers. It proved possible to freeze a single conformational state in CDCl, at 214 K. Unusual chemical shifta and nuclear Overhauser enhancements are consistent with the main features of the solid state structure.

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