Comparison of solid and solution conformations of hydroxyurea and 3-ethyl-1-hydroxyurea utilizing IR-X-ray method

✍ Scribed by George R. Parker; James D. Korp

• Book ID: 102914410
• Publisher: John Wiley and Sons
• Year: 1978
• Tongue: English
• Weight: 590 KB
• Volume: 67
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600670229

✦ Synopsis

cleavage was shown (11) to he a significant reaction in the hydrolysis of I1 in water.

Samples were analyzed using the three methods described (Table I). The total of I plus I1 calculated as I determined using Method A agrees with the total content of I determined after complete hydrolysis.This fact, together with the observation that 111 is the only reaction product formed from I1 and aniline, strongly indicates that Method A provides an accurate measurement of I and 11. With the exception of Sample a, only small deviations can be observed between the content of I1 determined by Methods A and B. This result may indicate that the value of t520 = 6200 M-' cm-' for I1 (4) is not correct and that using a value of ~5 2 0 = 6020M-' cm-I leads to improved agreement between the results of Methods A and B.

The methods described are intended to be applied to I1 and I in a 0.8 M solution of sodium gentisate (4). The present work shows that the reaction between I1 and aniline is applicable for the determination of a mixture of I and I1 in parenteral solutions and that spectrophotometric analysis of the reaction mixture appears to be a simple and reliable method of analysis.