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Comparison of single dose kinetics of imipramine, nortriptyline and antipyrine in man

✍ Scribed by Lars F. Gram; Per Buch Andreasen; Kerstin Fredricson Overø; Johannes Christiansen

Publisher
Springer
Year
1976
Tongue
English
Weight
678 KB
Volume
50
Category
Article
ISSN
0033-3158

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Comparison of single-dose pharmacokineti
Comparison of single-dose pharmacokinetics of imipramine and maprotiline in the elderly
✍ P. D. Hrdina; V. Rovei; J. F. Henry; M. P. Hervy; R. Gomeni; F. Forette; P. L. M 📂 Article 📅 1980 🏛 Springer 🌐 English ⚖ 488 KB

Pharmacokinetic profiles of imipramine and a newer tetracyclic antidepressant, maprotiline, were studied in elderly (75-83 years of age) subjects who were given a single oral dose of 125 and 175mg, respectively, of these drugs. The apparent elimination half-life of imipramine was 20.8 -34.9 h (mean