Comparison of sequence changes of precore and core promoter regions in HBeAg-positive chronic hepatitis B patients with and without HBeAg clearance in lamivudine therapy
β Scribed by Chien-Hung Chen; Chuan-Mo Lee; Sheng-Nan Lu; Chi-Sin Changchien; Jyh-Chwan Wang; Jing-Houng Wang; Chao-Hung Hung; Tsung-Hui Hu
- Book ID
- 116650894
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 124 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0168-8278
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## Abstract The aim of this study was to elucidate the longβterm outcome after interferon (IFN) or lamivudine (LMV) treatment in Japanese patients with hepatitis B e antigen (HBeAg) positive chronic hepatitis B. Inclusion criteria were biopsy proven chronic hepatitis or liver cirrhosis, no history
## Abstract The A1762T and G1764A mutations in the basal core promoter (BCP) region and the G1896A mutation in the precore (PC) region of hepatitis B virus (HBV) genome are found commonly in HBeAgβnegative patients. Experiments in vitro suggest that BCP and PC mutation reduce and abolish HBeAg expr